The Study of human Papillomavirus and precancerous Lesions In the Tonsil (SPLIT) project is an observational study started in 2012. The SPLIT project is funded by Institut National du Cancer (INCa), Association pour la Recherche sur le Cancer (ARC), and Ligue contre le Cancer as part of the French "Programme d'Actions Intégrées de Recherche - Cancers des Voies Aéro-Digestives Supérieures (PAIR - VADS) 2011".

Head and neck surgeons and pathologists from 17 recruiting centres and biologists from 7 research laboratories across France are collaborating to address the question of the natural history of human papillomavirus (HPV) infection in the tonsil.

The main objectives of SPLIT are to assess the prevalence of HPV detection by age categories in fresh specimens of non-cancerous tonsils and to examine putative cellular abnormalities with liquid-based cytology.

The SPLIT project will therefore elucidate the impact and cost-efficiency of new strategies for the prevention, early diagnosis, and treatment of HPV-associated malignancies in the upper aerodigestive tract.

STUDY COORDINATION

Surgery
Prof. Jean LACAU ST GUILY
ORL/CCF – Hôpital Tenon
AP-HP
Biology/Pathology
Prof. Christine CLAVEL
INSERM UMR-S903
CHU de Reims
Epidemiology
Dr Silvia FRANCESCHI
Infections and Cancer Epidemiology Group
IARC - Lyon


SPLIT NEWS


May 2014
Kick-off meeting at CHU Limoges.

January 2014
SPLIT Steering Committee Meeting in Lyon.

April 2013
SPLIT Steering Committee Meeting in Reims.

November-December 2012
Kick-off meetings at CHU Tours and CHU Toulouse.


September-October 2012
Kick-off meetings at CHU Besancon and CHU Strasbourg.


June-July 2012
Kick-off meetings at Hôpital Foch - Paris, HCL Lyon-Sud, CHU Poitiers, Hôpital Necker - Enfants Malades (AP-HP), Hôpital Armand-Trousseau (AP-HP), Hôpital Bichat (AP-HP), Hôpital Robert Debré (AP-HP), CHU Caen, CHU Nantes, Hôpital de la Pitié-Salpêtrière (AP-HP) and CHU Nîmes.


February-March 2012
Implementation of pilot studies at Hôpital Tenon (AP-HP) and CHU Reims.